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Ebola: Scientists a step forward towards finding cure

Health workers at an Ebola treatment centre

New research from the US Centers for Disease Control and Prevention (CDC) offers some hope, highlighting two treatments that could help bring Ebola outbreak under control.

More than 1,500 people have been reported to have died after a second outbreak of Ebola started in August 2018 in the Democratic Republic of the Congo (DRC). So, this is definitely good news for the health community and for sub-Sahara Africa in particular, where the disease is mostly concentrated.

The study, published in the The Lancet Infectious Diseases, finds that two experimental Ebola treatments—Gilead Sciences’ antiviral drug remdesivir, and antibodies included in a Mapp Biopharmaceutical cocktail known as ZMapp—were shown in a lab to slow the viral strain found in the DRC, potentially offering an effective treatment to those who become infected with the hemorrhagic fever.

There is no known cure for Ebola. There are some treatments available, but all were “developed to fight Ebola viruses from previous outbreaks,” lead study author and CDC microbiologist Laura McMullan says in a statement. “It’s vitally important to make sure existing treatments work against the virus that’s making people sick now.”

CDC researchers isolated and recreated the specific viral strain circulating in the DRC, which is known as the Ituri strain, and studied its activity in human cells in a secure laboratory. This allowed them to compare the Ituri strain to past forms of Ebola, and to test treatments with a high degree of specificity. They also confirmed that diagnostic tests currently in use in the DRC can accurately detect Ebola.

While remdesivir and ZMapp could offer relief to those who are already sick with Ebola, a vaccine made by Merck is also showing promise at preventing transmission in the first place.

Merck’s vaccine is still experimental and has not yet been approved by government agencies. However, according to the Time, it has been used in the DRC under “compassionate use” rules, which allow drugs under investigation to be used in the absence of other options. World Health Organization data suggest the vaccine has about a 97.5% efficacy rate. A 2016 trial conducted in Guinea, one of the countries ravaged by Ebola during a West African outbreak that killed more than 11,000 people from 2014 to 2016, also suggested the vaccine could effectively prevent infection.

The DRC outbreak has yet to reach that scale, but its continuing intensity and recent presence in neighbouring Uganda—and the sociopolitical challenges that have hampered response efforts—have health officials worried. The CDC says its results “support the continued testing of remdesivir and ZMapp in DR Congo,” which could, at least, offer some help.



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Ebola: Scientists a step forward towards finding cure